Potassium Carbonate → N-(2-amino-5-(4-boc-1-piperazinyl)-phenyl)-benzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

A mixture of N-(2-nitro-3-fluorophenyl)-benzenesulfonamide (4.68 g, 15.7 mmol), Boc-piperazine (3.5 g, 18.9 mmol) and K2CO3 (3.8 g, 27.8 mmol) in DMF was stirred at 70° C. for 24 h. The mixture was filtered and purified by column chromatography (SiO2, CH2Cl2/MeOH/heptane/NH3 4:1:5:0.2%) to give 2.0 g of desired product. 1H-NMR δ 7.98 (d, 1H), 7.89–7.84 (m, 2H), 7.63–7.50 (m, 3H), 7.00 (d, 1H), 6.68 (dd, 1H), 3.59–3.45 (m, 8H), 1.49 (s, 9H); MS (posES-FIA) m/z=found: 485.0 (M++Na+). The product (1.85 g, 4.00 mmol) was dissolved in EtOH:THF (4:1) followed by addition of Raney-Ni and hydrazine (1.0 mL, 20 mmol). The reaction was stirred at room temperature for 3 h until the yellow color disappeared. Filtration through wet Celite, followed by removal of the solvent afforded 1.26 g of N-(2-amino-5-(4-tert-butoxycarbonyl-1-piperazinyl)-phenyl)-benzenesulfonamide which was used without further purification.

Provenance & Evidence