2,4-Difluorobenzenesulfonyl Chloride → HCID 10207636, compound

Participants

Reaction Steps

2,4-Difluoro-N-[2-[(phenylsulfonyl)amino]-4-(1-piperazinyl)phenyl] benzenesulfonamide was synthesized from N-{2-amino-5-(4-t-butyloxycarbonyl-piperazinyl)-phenyl}benzenesulfonamide and 2,4-difluorobenzenesulfonylchloride (94 mg, 0.455 mmol) according to general method 3 to give before Boc-deprotection 160 mg of a purple solid. MS (posES-FIA) m/z=Found: 509.1; Calcd 509.11; 1H-NMR δ 77.71–7.46 (m, 6H), 7.25–7.17 (m, 1H), 7.03–6.96 (m, 2H), 6.72 (dd, 1H), 6.44 (d, 1H), 3.20–3.16 (m, 8H).

Provenance & Evidence