1-Naphthalenesulfonyl chloride → HCID 10229358, compound

HRID 346750Notes

Reaction equation

HRID 346750 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[NH:22][S:23]([CH3:26])(=[O:25])=[O:24].[C:27]1([S:37]([Cl:40])(=[O:39])=[O:38])[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][CH:28]=1>>[ClH:40].[N:8]1([C:5]2[CH:6]=[CH:7][C:2]([NH:1][S:37]([C:27]3[C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH:30]=[CH:29][CH:28]=3)(=[O:39])=[O:38])=[C:3]([NH:22][S:23]([CH3:26])(=[O:24])=[O:25])[CH:4]=2)[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 665601-Naphthalenesulfonyl chlorideHCID 22272520HCID 22272520, compound

Product 1

HCID 10229358HCID 10229358, compound

Procedure

The compound was synthesized from N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}methanesulfonamide and 1-napthalenesufonylchloride (103 mg, 0.455 mmol) to give before Boc-deprotection 150 mg of a purple solid. M+1 475.1 Calcd 474.14.

Workup

  1. customto give before Boc-deprotection 150 mg of a purple solid

Sources & evidence

ORD record
ord-7048994c2fc54c10aeab99c995e9c97f
Source dataset
uspto-grants-2007_02
Patent number
US07173035B2

Reaction notes

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