4-Fluorobenzenesulfonyl chloride → HCID 10299388, compound

HRID 346752Notes

Reaction equation

HRID 346752 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[NH:22][S:23]([CH3:26])(=[O:25])=[O:24].[F:27][C:28]1[CH:33]=[CH:32][C:31]([S:34]([Cl:37])(=[O:36])=[O:35])=[CH:30][CH:29]=1>>[ClH:37].[N:8]1([C:5]2[CH:6]=[CH:7][C:2]([NH:1][S:34]([C:31]3[CH:32]=[CH:33][C:28]([F:27])=[CH:29][CH:30]=3)(=[O:36])=[O:35])=[C:3]([NH:22][S:23]([CH3:26])(=[O:24])=[O:25])[CH:4]=2)[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 22272520HCID 22272520, compound

Product 1

HCID 10299388HCID 10299388, compound

Procedure

The compound was synthesized from N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}methanesulfonamide and 4-fluorobenzenesulfonylchloride (89 mg, 0.455 mmol) to give before Boc-deprotection 170 mg of a purple solid. M+1 443.1 Calcd 443.11.

Workup

  1. customto give before Boc-deprotection 170 mg of a purple solid

Sources & evidence

ORD record
ord-5a9caebdae054625b593a325721b7941
Source dataset
uspto-grants-2007_02
Patent number
US07173035B2

Reaction notes

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