3,5-Dimethylisoxazole-4-sulfonyl chloride → HCID 10299445, compound

HRID 346757Notes

Reaction equation

HRID 346757 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[NH:22][S:23]([CH3:26])(=[O:25])=[O:24].[CH3:27][C:28]1[C:32]([S:33]([Cl:36])(=[O:35])=[O:34])=[C:31]([CH3:37])[O:30][N:29]=1>>[ClH:36].[N:8]1([C:5]2[CH:6]=[CH:7][C:2]([NH:1][S:33]([C:32]3[C:28]([CH3:27])=[N:29][O:30][C:31]=3[CH3:37])(=[O:35])=[O:34])=[C:3]([NH:22][S:23]([CH3:26])(=[O:24])=[O:25])[CH:4]=2)[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 27363193,5-Dimethylisoxazole-4-sulfonyl chlorideHCID 22272520HCID 22272520, compound

Product 1

HCID 10299445HCID 10299445, compound

Procedure

The compound was synthesized from N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}methanesulfonamide and 3,5-dimethylisoxazole-4-sulfonylchloride (89 mg, 0.455 mmol) 3 to give 120 mg of as purple solid. M+1 444.2 Calcd 444.13.

Workup

  1. customto give 120 mg of as purple solid

Sources & evidence

ORD record
ord-f0cf6d11dbc6445fa1991676b4cdac5e
Source dataset
uspto-grants-2007_02
Patent number
US07173035B2

Reaction notes

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