Hydrochloric Acid → HCID 10227348, compound

Participants

Reaction Steps

tert-Butyl 4-{4-{[(4-methylphenyl)sulfonyl]amino}-3-[(methylsulfonyl)amino]phenyl}-1,4-diazepane-1-carboxylate (0.5 g) was dissolved in methanol (15 mL). A solution of HCl in ethyl acetate (1N, 25 mL) was added and the mixture stirred for 2 hours. Ether (200 mL) was added and the mixture stirred for 3 hours to allow full precipitation. The product was collected by filtration, washed with ether and dried. Yield 0.43 g (98%) 1H NMR (400 MHz, DMSO-d6) δ 2.03 (m, 2 H), 2.36 (s, 3 H), 2.9 (s, 3H), 3.02–3.09 (br m, 2 H), 3.11–3.19 (br m, 2 H), 3.41 (br t, J=7.08 Hz, 2 H), 3.63 (br m, 2 H), 6.46 (d ab, J=2.8 Hz, 8.8 Hz, 1 H), 6.62 (ab, J=8.8 Hz, 1 H), 6.71 (d, J=2.8 Hz, 1 H), 7.36 (ab, J=8.3 Hz, 2 H), 7.58 (ab, J=8.3 Hz, 2 H), 8.39 (s, 1 H), 9.2 (br, 2 H). 9.8 (s, 1 H), MS (ESI+) for C19H27N4O4S2 m/z 439.148 (M+H)+ (Calculated 439.1474).

Provenance & Evidence