1-Naphthalenesulfonyl chloride → N-{4-(1,4-diazepan-1-yl)-2-[(phenylsulfonyl)amino]phenyl}-1-naphthalenesulfonamide hydrochloride

Participants

Reaction Steps

The compound was synthesized from of N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}benzenesulfonamide and 1-naphthalenesulfonylchloride (61 mg, 0.27 mmol) to give 56 mg as purple solid. M+1 537.2 Calcd 537.15; 1HNMR δ 8.67–8.64 (m, 1H), 8.10 (d, 1H), 8.02–7.98 (m, 1H), 7.89 (dd, 1H), 7.77–7.38 (m, 8H), 6.46 (d, 1H), 6.26 (d, 1H), 6.14 (dd, 1H), 3.54 (app t, 2H), 3.36–3.31 (m, 2H), 3.17 (app t, 2H), 2.05–1.96 (m, 2H).

Provenance & Evidence