HCID 11583897, compound → HCID 11677393, compound

HRID 346824Notes

Reaction equation

[F:1][C:2]([F:34])([F:33])[C:3]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][C:19]1[N:20]=[C:21]([C:25]3[CH:26]=[C:27]([CH3:31])[CH:28]=[CH:29][CH:30]=3)[O:22][C:23]=1[CH3:24])[CH:13]([CH3:32])[CH2:12]2)([OH:8])[C:4]([F:7])([F:6])[F:5]>C1(C)C=CC=CC=1.O=[Mn]=O>[F:6][C:4]([F:5])([F:7])[C:3]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][C:19]1[N:20]=[C:21]([C:25]3[CH:26]=[C:27]([CH3:31])[CH:28]=[CH:29][CH:30]=3)[O:22][C:23]=1[CH3:24])[C:13]([CH3:32])=[CH:12]2)([OH:8])[C:2]([F:34])([F:33])[F:1]

Participants

Conditions

Temperature: 70 °C

Procedure

To a solution of 32 mg (0.07 mmol) of 1,1,1,3,3,3-hexafluoro-2-[2-methyl-1-(5-methyl-2-m-tolyl-oxazol-4-ylmethyl)-2,3-dihydro-1H-indol-5-yl]-propan-2-ol (example 47) in 0.5 mL of toluene were added 29 mg (0.33 mmol) of MnO2 powder and the mixture was stirred at 70° C. for 10 hrs. Filtration and evaporation of the solvent gave 33 mg (quantitative) of 1,1,1,3,3,3-hexafluoro-2-[2-methyl-1-(5-methyl-2-m-tolyl-oxazol-4-ylmethyl)-1H-indol-5-yl]-propan-2-ol, grey solid, MS: 483 (MH+).

Workup

filtrationFiltration and evaporation of the solvent

Sources & evidence

ORD record: ord-84c1482c5e2a41a898ff43c39207782f
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07173048B2

Reaction notes

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