1-(4-(Trifluoromethyl)phenyl)ethan-1-one → 5-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

HRID 346853Notes

Reaction equation

HRID 346853 reaction equation
[Cl:1][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[C:13](OC)[C:12](OC)=[C:11](OC)[CH:10]=2)[CH:4]=1.CC(C1C=CC([C:30]([F:33])([F:32])[F:31])=CC=1)=O>>[Cl:1][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:30]([F:33])([F:32])[F:31])=[CH:11][CH:10]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 697311-(4-(Trifluoromethyl)phenyl)ethan-1-oneHCID 184084865-Chloromethyl-1-methyl-3-(3,4,5-trimethoxy-phenyl)pyrazole

Product 1

HCID 210822245-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole

Procedure

5-chloromethyl-1-methyl-3-(4-trifluoromethyl-phenyl)-1H-pyrazole was prepared in analogy to the preparation of 5-chloromethyl-1-methyl-3-(3,4,5-trimethoxy-phenyl)-1H-pyrazole described by Kodama et al. (U.S. Pat. No. 6,472,386), but starting from 4-trifluoromethylacetophenone instead of 3′4′5′-trimethoxyacetophenone.

Sources & evidence

ORD record
ord-d47885a2419d4141bea517bc27107419
Source dataset
uspto-grants-2007_02
Patent number
US07173048B2

Reaction notes

Loading…