HCID 11613417, compound → HCID 21082180, compound

HRID 346861Notes

Reaction equation

C[O:2][C:3](=[O:37])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[O:11][C:12]([CH3:36])=[C:13]([CH2:15][N:16]3[C:24]4[C:19](=[CH:20][C:21]([C:25]([OH:34])([C:30]([F:33])([F:32])[F:31])[C:26]([F:29])([F:28])[F:27])=[CH:22][CH:23]=4)[CH2:18][CH:17]3[CH3:35])[N:14]=2)[CH:5]=1.CC1OC(C2C=C(C=CC=2)C(O)=O)N(CN2C3C(=CC(C(O)(C(F)(F)F)C(F)(F)F)=CC=3)C=C2C)C=1>>[CH3:36][C:12]1[O:11][C:10]([C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:37])=[O:2])=[N:14][C:13]=1[CH2:15][N:16]1[C:24]2[C:19](=[CH:20][C:21]([C:25]([OH:34])([C:30]([F:33])([F:32])[F:31])[C:26]([F:27])([F:28])[F:29])=[CH:22][CH:23]=2)[CH:18]=[C:17]1[CH3:35]

Participants

Reactant 2

HCID 11613417HCID 11613417, compound

HCID 21082215HCID 21082215, compound

Product 1

HCID 21082180HCID 21082180, compound

Procedure

In analogy to example 91, from 3-{5-methyl-4-[2-methyl-5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-2,3-dihydro-indol-1-ylmethyl]-oxazol-2-yl}-benzoic acid methyl ester (example 120) was prepared 3-{5-methyl-3-[2-methyl-5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-indol-1-ylmethyl]-oxazol-2-yl}-benzoic acid, brown solid, MS: 513 (MH+).

Sources & evidence

ORD record: ord-d7e4fcc7aa494ff0a896ab17eef8da70
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07173048B2

Reaction notes

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