反应详情

A solution of the compound from Example 2(ii)(6 g, 24 mmol) in DCM was stirred at 0° C. Thionyl chloride was added drop-wise and the reaction was heated at reflux for 24 hrs. The reaction was allowed to cool and the solvents removed under vacuum to afford the expected compound as a pungent crude solid. 5.9 g, 100%. The solid was used without further purification.

1. temperaturethe reaction was heated
2. temperatureat reflux for 24 hrs
3. temperatureto cool
4. customthe solvents removed under vacuum