HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 6-Hydroxy-2H-1,4-benzoxazin-3(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-Chloro-N-(2,5-dihydroxy-phenyl)-acetamide | HCID 21298677 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Hydroxy-2H-1,4-benzoxazin-3(4H)-one | HCID 11378689 | — |
Reaction Steps
30% sodium methoxide in methanol (18.4 g, 0.075 mole) was added under stirring to the 2-(α-chloroacetamido)-hydroquinone (13.4 g, 0.075 mole) in dimethylformamide (DMF 10 ml). The resulting solution was poured into water (150 ml) and the separated solid was Coupler (1) (9 g, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762925 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-b52cafd4e953474a8c6bb7c03f548191 |
| Source note | uspto-grants-1988_08 |