Phosphorus oxychloride → HCID 17976094, compound

Participants

Reaction Steps

A mixture of intermediate (38) (0.0103 mol) in phosphoryl chloride (20 ml) was stirred and refluxed for 1 hour. The mixture was cooled to room temperature and evaporated till dryness. The residue was taken up in DCM. This solution was poured out into ice/NH4OH and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated. The residue (5.3 g) was crystallized from 2-propanone/DIPE. The precipitate was filtered off and dried, yielding 4.25 g (82%) of [2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](4-iodophenyl)-methanone, mp. 153° C. (intermediate 39).

Provenance & Evidence