Water → HCID 21082066, compound

Participants

Reaction Steps

Sulfuric acid (25 ml) was added slowly to H2O (25 ml). Acetic acid (25 ml) was added. Intermediate (59) (0.0190 mol) was added portionwise. The mixture was stirred and refluxed for 18 hours then cooled, poured out into ice water and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated till dryness. The residue (8.9 g) was taken up in EtOAc. The organic layer was separated, washed several times with water, dried (MgSO4), filtered and the solvent was evaporated till dryness, yielding 7.8 g (91%) of 5-(3-chlorophenyl)-α-(4-chlorophenyl)-tetrazolo[1,5-a]quinoline-7-acetic acid, MS (ESI) m/z:449, 451, 453 (MH+) (intermediate 60).

Provenance & Evidence