HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [4-(3-Chlorophenyl)-2-methoxy-6-quinolinyl](3-iodophenyl)-methanone | HCID 21082028 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone | HCID 21082035 | 88% |
Reaction Steps
A solution of intermediate (73) (0.0304 mol) in HCl 3N (150 ml) and THF (70 ml) was stirred and refluxed overnight, brought to room temperature, poured out into ice water and basified with potassium carbonate. The precipitate was filtered, washed with 2-propanone and dried, yielding 13 g (88%) of 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone (intermediate 74).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07173040B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-df125b2042124c39917f6eb35422eafd |
| Source note | uspto-grants-2007_02 |