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HRID3470

反应详情

EQUATION

反应方程式

HRID 3470 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)N=C=O
HCID62412

tert-Butyl isocyanate

C5H9NO

结构：Cc1cc(C)c(C)c(-c2cc3cnc(N)nc3nc2N)c1C
HCID5328124

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C)c(C)c(-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C)c1C
HCID5328125

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 0.3 g of 6-(2,3,5,6-tetramethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 98 and 0.125 mL of tert-butyl isocyanate according to Example 2. The product was purified by medium pressure liquid chromatography eluting with 1:1CHCl3 :EtOAc; mp >300° C.; CIMS (1% ammonia in methane): m/z (relative intensity) 393 (MH+, 55), 394 (MH+ +1, 13), 84 (100).

WORKUP

后处理

  1. customThe product was purified by medium pressure liquid chromatography
  2. washeluting with 1:1CHCl3