Thionyl Chloride → HCID 21082087, compound

HRID 347009Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:26]4[CH:31]=[CH:30][C:29]([I:32])=[CH:28][CH:27]=4)([C:20]4[N:24]([CH3:25])[CH:23]=[N:22][N:21]=4)O)[CH:16]=3)[N:11]3[N:33]=[N:34][N:35]=[C:10]3[N:9]=2)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:38])=O>>[ClH:1].[Cl:38][C:18]([C:26]1[CH:31]=[CH:30][C:29]([I:32])=[CH:28][CH:27]=1)([C:20]1[N:24]([CH3:25])[CH:23]=[N:22][N:21]=1)[C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]1[N:33]=[N:34][N:35]=[C:10]1[N:9]=[C:8]2[C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 21082069HCID 21082069, compound

Product 1

HCID 21082087HCID 21082087, compound

Conditions

Temperature: 65 °C

Procedure

A mixture of 5-(3chlorophenyl)-α-(4-iodophenyl)-α-(4-methyl-4H-1,2,4-triazol-3-yl)-tetrazolo[1,5-a]quinazoline-7-methanol (0.0076 mol) in thionyl chloride (50 ml) was stirred at 65° C. for 4 hours, then cooled and the solvent was evaporated till dryness. The residue was taken up twice with DCM. The solvent was evaporated, yielding 7-[chloro(4-iodophenyl)(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-5-(3-chlorophenyl)-tetrazolo[1,5-a]quinazoline monohydrochloride. This product was used directly in the next reaction step.

Workup

temperaturecooled
customthe solvent was evaporated till dryness
customThe solvent was evaporated

Sources & evidence

ORD record: ord-0d98cec6ce154dc38981d364acd270c1
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07173040B2

Reaction notes

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