Hydrochloric Acid → {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	N-(2-Methoxyethyl)ethylamine	HCID 546877	—
Reactant	HCID 22313931	HCID 22313931	—
Reactant	{4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine	HCID 22314065	—
Solvent	Methanol	HCID 887	—
Product	{4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine hydrochloride	HCID 22314064	—

Reaction Steps

In analogy to example 3.1, 6-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[d]isothiazole and N-(2-Methoxyethyl)ethylamine were converted to {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine which was converted to the hydrochloride by treatment with HCl in methanol to yield {4-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-ethyl-(2-methoxy-ethyl)-amine hydrochloride as light yellow oil, MS: 463 (MH+, 1Br).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07173043B2
Source dataset	uspto-grants-2007_02
ORD ID	ord-c6a97a596d694a15983d25a78828c886
Source note	uspto-grants-2007_02