(R)-3-Pyrrolidinol → HCID 69289055, compound

HRID 347085Notes

Reaction equation

HRID 347085 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:22]=[CH:21][C:10]2[C:11]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)=[N:12][S:13][C:9]=2[CH:8]=1.[OH:23][C@@H:24]1[CH2:28][CH2:27][NH:26][CH2:25]1>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:11]2[C:10]3[CH:21]=[CH:22][C:7]([O:6][CH2:5][CH2:4][CH2:3][CH2:2][N:26]4[CH2:27][CH2:28][C@@H:24]([OH:23])[CH2:25]4)=[CH:8][C:9]=3[S:13][N:12]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 2759337(R)-3-PyrrolidinolHCID 223139036-(4-Bromo-butoxy)-3-(4-chloro-phenyl)-benzo[d]isothiazole

Product 1

HCID 69289055HCID 69289055, compound

Procedure

According to the method in example 7, 6-(4-Bromo-butoxy)-3-(4-chloro-phenyl)-benzo[d]isothiazole and (R)-3-Hydroxypyrrolidine were converted to yield (3R)-1-{4-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yloxy]-butyl}-pyrrolidin-3-ol, MS: 403 (MH+, 1Cl).

Sources & evidence

ORD record
ord-5c69cc4ac831452287214b68fe2f215f
Source dataset
uspto-grants-2007_02
Patent number
US07173043B2

Reaction notes

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