(2-Methoxyphenyl)acetonitrile → 6-(2-Methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

HRID 3471Notes

Reaction equation

HRID 3471 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][C:6]#[N:7].[NH2:12][C:13]1[N:18]=[C:17]([NH2:19])[C:16]([CH:20]=O)=[CH:15][N:14]=1>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]1[C:6]([NH2:7])=[N:19][C:17]2[N:18]=[C:13]([NH2:12])[N:14]=[CH:15][C:16]=2[CH:20]=1

Participants

3

Reactant 2

HCID 81496(2-Methoxyphenyl)acetonitrileHCID 3091762,4-Diaminopyrimidine-5-carbaldehyde

Product 1

HCID 218500336-(2-Methoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Procedure

The title compound was prepared according to Example 1, starting from 2-methoxybenzyl cyanide and 2,4-diamino-5-pyrimidine-carboxaldehyde; mp 304°-306° C. (dec).

Sources & evidence

ORD record
ord-74d6fcc0722a4bd7bcda26708f3e9dee
Source dataset
uspto-grants-1998_03
Patent number
US05733913

Reaction notes

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