Methanesulfonyl chloride → HCID 86585424, compound

HRID 347140Notes

Reaction equation

[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:13]3[CH:14]=[CH:15][C:16]([CH2:18][CH2:19][CH2:20][CH2:21][OH:22])=[CH:17][C:12]=3[S:11][N:10]=2)=[CH:5][CH:4]=1.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>>[F:24][C:2]([F:1])([F:23])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:13]3[CH:14]=[CH:15][C:16]([CH2:18][CH2:19][CH2:20][CH2:21][O:22][S:26]([CH3:25])(=[O:28])=[O:27])=[CH:17][C:12]=3[S:11][N:10]=2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 22314120HCID 22314120, compound

Product 1

HCID 86585424HCID 86585424, compound

Procedure

In analogy to example 21.1, 4-[3-(4-Trifluoromethyl-phenyl)-benzo[d]isothiazol-6-yl]-butan-1-ol and methanesulfonic acid chloride were converted to yield Methanesulfonic acid 4-[3-(4-trifluoromethyl-phenyl)-benzo[d]isothiazol-6-yl]-butyl ester, MS: 430 (MH+).

Sources & evidence

ORD record: ord-30b2bc688f144d02bf9134babd579f31
Source dataset: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07173043B2

Reaction notes

Loading…