{3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-dimethyl-amine → {3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-propyl}-dimethyl-amine

Participants

Role	Name	HCID	Charge
Reactant	{3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-dimethyl-amine	HCID 22313967	—
Catalyst	Adams' catalyst	HCID 345198	—
Solvent	Ethanol	HCID 702	—
Product	{3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-propyl}-dimethyl-amine	HCID 22314100	53%

Reaction Steps

80 mg (0.25 mmol) {3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-prop-2-ynyl}-dimethyl-amine in 2 ml EtOH were hydrogenated in the presence of 20 mg PtO2. H2O, purification by flash silica gel column (CH2Cl2/MeOH 9:1) yielded 43 mg (53%) {3-[3-(4-Chloro-phenyl)-benzo[d]isothiazol-6-yl]-propyl}-dimethyl-amine as a colorless oil, MS: 331 (MH+, 1Cl).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07173043B2
Source dataset	uspto-grants-2007_02
ORD ID	ord-4f6080bbc7d8474c8bd7e64a69884d38
Source note	uspto-grants-2007_02