Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 1-(4-Fluoro-phenyl)-2-(3-methoxy-phenylsulfanyl)-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 3-Methoxybenzenethiol | HCID 84989 | — |
| 반응물 | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(4-Fluoro-phenyl)-2-(3-methoxy-phenylsulfanyl)-ethanone | HCID 11033114 | 104.5% |
반응 단계
14.27 ml (115.0 mmol) 3-mercaptoanisole were added to a solution of 7.3 g (115.0 mmol) KOH in 120 ml ethanol and 50 ml water. 25.0 g (115.2 mmol) 4-fluorophenacyl bromide in 120 ml EtOAc were added slowly at 0° C. and the solution was stirred at RT over night. The suspension was concentrated and dissolved in EtOAc and water. The inorganic phase was extracted with EtOAc, the combined organic phases were washed with water and brine and dried over Na2SO4. Evaporation yielded 33.2 g crude 1-(4-Fluoro-phenyl)-2-(3-methoxy-phenylsulfanyl)-ethanone as light yellow liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07173043B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-fe2fc994591148b99cfd128dbe4c3797 |
| 출처 메모 | uspto-grants-2007_02 |