1,4-Dibromobutane → 6-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[b]thiophene

Participants

Role	Name	HCID	Charge
Reactant	1,4-Dibromobutane	HCID 8056	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	3-(4-Bromo-phenyl)-benzo[b]thiophen-6-ol	HCID 17932888	—
Solvent	Acetone	HCID 180	—
Product	6-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[b]thiophene	HCID 22314056	93.6%

Reaction Conditions

Temperature	45 °C

Reaction Steps

2.0 g (6.55 mmol) 3-(4-Bromo-phenyl)-benzo[b]thiophen-6-ol in 25 ml acetone were treated with 5.89 g (42.6 mmol, 6.5 eq) K2CO3 and 2.0 ml (16.38 mmol, 2.5 eq) 1,4-dibromobutane. The reaction mixture was stirred at 45° C. for 10 h, filtered and evaporated. The excess of dibromide was removed in vacuo to yield 2.7 g crude 6-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[b]thiophene, MS: 439 (M).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07173043B2
Source dataset	uspto-grants-2007_02
ORD ID	ord-48f1c044e12949d1aa7a1f6852fc9a3a
Source note	uspto-grants-2007_02