1,4-Dibromobutane → 6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene

HRID 347164Notes

Reaction equation

HRID 347164 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[Br:18][CH2:19][CH2:20][CH2:21][CH2:22]Br>>[Br:18][CH2:19][CH2:20][CH2:21][CH2:22][O:17][C:14]1[CH:15]=[CH:16][C:9]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:12][S:11][C:10]=2[CH:13]=1

Participants

3

Reactant 2

HCID 80561,4-DibromobutaneHCID 223141963-(4-Fluoro-phenyl)-benzo[b]thiophen-6-ol

Product 1

HCID 223139386-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene

Procedure

In analogy to example 27.1, 3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-ol and 1,4-dibromobutane were converted to yield 6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene, MS: 378 (M, 1Br).

Sources & evidence

ORD record
ord-56a32166a0934fe3a82d3212243edba7
Source dataset
uspto-grants-2007_02
Patent number
US07173043B2

Reaction notes

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