Dimethylamine → [4-[3-(4-Bromo-phenyl)-benzo[b]thiophen-6-yloxy]-butyl]-dimethyl-amine

HRID 347167Notes

Reaction equation

HRID 347167 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([Br:21])=[CH:17][CH:16]=3)=[CH:13][S:12][C:11]=2[CH:22]=1.[CH3:23][NH:24][CH3:25]>C(O)C>[Br:21][C:18]1[CH:19]=[CH:20][C:15]([C:14]2[C:10]3[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][CH2:3][CH2:2][N:24]([CH3:25])[CH3:23])=[CH:22][C:11]=3[S:12][CH:13]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 223140566-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[b]thiophene

Product 1

HCID 22314015[4-[3-(4-Bromo-phenyl)-benzo[b]thiophen-6-yloxy]-butyl]-dimethyl-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In analogy to example 3.1, 6-(4-Bromo-butoxy)-3-(4-bromo-phenyl)-benzo[b]thiophene and N,N-dimethylamine in ethanol were converted to yield [4-[3-(4-Bromo-phenyl)-benzo[b]thiophen-6-yloxy]-butyl]-dimethyl-amine as light yellow semisolid, MS: 404 (MH+, 1Br).

Sources & evidence

ORD record
ord-888007644d184104b5c850bc420e1c10
Source dataset
uspto-grants-2007_02
Patent number
US07173043B2

Reaction notes

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