3-Butyn-1-OL → HCID 22314043, compound

HRID 347236Notes

Reaction equation

HRID 347236 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=[CH:10][C:4]=2[C:3]=1[C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=1.[CH2:29]([OH:33])[CH2:30][C:31]#[CH:32]>>[CH3:1][C:2]1[S:6][C:5]2[CH:7]=[C:8]([C:32]#[C:31][CH2:30][CH2:29][OH:33])[CH:9]=[CH:10][C:4]=2[C:3]=1[C:19]1[CH:20]=[CH:21][C:22]([C:25]([F:27])([F:28])[F:26])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 135663-Butyn-1-OLHCID 86585425HCID 86585425, compound

Product 1

HCID 22314043HCID 22314043, compound

Procedure

In analogy to example 13.1, the Trifluoro-methanesulfonic acid 2-methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-yl ester was reacted with 3-butyn-1-ol to yield the 4-[2-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-yl]-but-3-yn-1-ol as brown oil, MS: 360 (M+).

Sources & evidence

ORD record
ord-133e69bf4c114524bdef880952546445
Source dataset
uspto-grants-2007_02
Patent number
US07173043B2

Reaction notes

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