4-Pentyn-1-ol → HCID 22314058, compound

HRID 347238Notes

Reaction equation

HRID 347238 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14](OS(C(F)(F)F)(=O)=O)=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[CH2:25]([OH:30])[CH2:26][CH2:27][C:28]#[CH:29]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([C:29]#[C:28][CH2:27][CH2:26][CH2:25][OH:30])=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 793464-Pentyn-1-olHCID 86585426HCID 86585426, compound

Product 1

HCID 22314058HCID 22314058, compound

Procedure

In analogy to example 14.1, Trifluoro-methanesulfonic acid 3-(4-fluoro-phenyl)-benzo[b]thiophene-6-yl ester and 4-pentyn-1-ol were converted to yield 5-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yl]-pent-4-yn-1-ol as light green solid, MS: 310 (M).

Sources & evidence

ORD record
ord-5ae66c6135814ced9031dcfe9102294d
Source dataset
uspto-grants-2007_02
Patent number
US07173043B2

Reaction notes

Loading…