2-(Ethylamino)ethanol → HCID 22314122, compound

HRID 347242Notes

Reaction equation

HRID 347242 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([C:17]#[C:18][CH2:19][CH2:20][CH2:21]O)=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[CH2:23]([NH:25][CH2:26][CH2:27][OH:28])[CH3:24]>>[CH2:23]([N:25]([CH2:21][CH2:20][CH2:19][C:18]#[C:17][C:14]1[CH:15]=[CH:16][C:9]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[CH:12][S:11][C:10]=2[CH:13]=1)[CH2:26][CH2:27][OH:28])[CH3:24]

Participants

3

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 22314058HCID 22314058, compound

Product 1

HCID 22314122HCID 22314122, compound

Procedure

In analogy to example 19.1, 5-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yl]-pent-4-yn-1-ol and 2-(Ethylamino)ethanol were converted to yield 2-(Ethyl-{5-[3-(4-fluoro-phenyl)-benzo[b]thiophen-6-yl]-pent-4-ynyl}-amino)-ethanol as light brown oil, MS: 382 (MH+).

Sources & evidence

ORD record
ord-8dc45959cd6349bd96bea1fea903c4ef
Source dataset
uspto-grants-2007_02
Patent number
US07173043B2

Reaction notes

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