N-(2-Methoxyethyl)ethylamine → HCID 22314019, compound

HRID 347244Notes

Reaction equation

HRID 347244 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([C:17]#[C:18][CH2:19][CH2:20][CH2:21]O)=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[CH3:23][O:24][CH2:25][CH2:26][NH:27][CH2:28][CH3:29]>>[CH2:28]([N:27]([CH2:21][CH2:20][CH2:19][C:18]#[C:17][C:14]1[CH:15]=[CH:16][C:9]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[CH:12][S:11][C:10]=2[CH:13]=1)[CH2:26][CH2:25][O:24][CH3:23])[CH3:29]

Participants

3

Reactant 2

HCID 546877N-(2-Methoxyethyl)ethylamineHCID 22314058HCID 22314058, compound

Product 1

HCID 22314019HCID 22314019, compound

Procedure

In analogy to example 19.1, 5-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yl]-pent-4-yn-1-ol and N-(Methoxyethyl)ethylamine were converted to yield Ethyl-{5-[3-(4-fluoro-phenyl)-benzo[b]thiophen-6-yl]-pent-4-ynyl}-(2-methoxy-ethyl)-amine as light brown oil, MS: 396 (MH+).

Sources & evidence

ORD record
ord-b8e4335c09f1423eadf0646b060916b8
Source dataset
uspto-grants-2007_02
Patent number
US07173043B2

Reaction notes

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