1H-Indole-1-ethanamine, 5-fluoro-2,3-dihydro- → (S)-2-(Benzooxazol-2-ylamino)-3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-propionamide
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C@@H:11]([CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[C:12]([OH:14])=O.[F:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[N:28]([CH2:32][CH2:33][NH2:34])[CH2:27][CH2:26]2>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C@@H:11]([CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[C:12]([NH:34][CH2:33][CH2:32][N:28]1[C:29]2[C:25](=[CH:24][C:23]([F:22])=[CH:31][CH:30]=2)[CH2:26][CH2:27]1)=[O:14]Participants
3
Procedure
The title compound was prepared from 2-(S)-(benzooxazol-2-ylamino)-3-cyclohexyl propionic acid and 2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethylamine using the procedure analogous to that described in example 2. HPLC-MS calcd. for C26H31FN4O2 (M+H+) 451.24. found 451.5.
Sources & evidence
- ORD record
- ord-a8950b19774649588924dd565d4be6aa
- Source dataset
- uspto-grants-2007_02
- Patent number
- US07173051B2
Reaction notes
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