3-Cyclohexyl-L-alanine → (2S)-3-cyclohexyl-2-[(5-fluoro-1,3-benzoxazol-2-yl)amino]-N-{2-[(4-fluorophenyl)amino]ethyl}propanamide

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Reaction Steps

The title compound was prepared from 2-chloro-5-fluorobenzoxazole, L-cyclohexylalanine and N1-(4-fluoro-phenyl)-ethane-1,2-diamine.2HCl using the procedure analogous to that described in example 2. 1H NMR (DMSO-d6, 400 MHz) δ 8.29 (d, 1H, J=8.0 Hz), 8.16 (t, 1H, J=5.6 Hz), 7.27 (dd, 1H, J=4.4 Hz, J=8.4 Hz), 6.97 (dd, 1H, J=2.6 Hz, J=9.4 Hz), 6.80 (m, 2H), 6.72(m, 1H), 6.46(m, 2H), 5.42(m, 1H), 4.20 (m, 1H), 3.15(m, 2H), 2.95(m, 2H), 1.55(m, 7H), 1.30(m, 1H), 1.05(m, 3H), 0.83(m, 2H). HPLC-MS calcd. for C24H28F2N4O2(M+H+) 443.22. found 443.5.

Provenance & Evidence