Sodium Hydroxide → HCID 21082765, compound

Participants

Reaction Steps

To 7S (2.11 g, 5.24 mmol) was added a solution of sodium hydroxide (295 mg, 7.38 mmol) in methanol (10.5 ml). After stirring for 18 h at rt, the reaction mixture was concentrated in vacuo. After addition of water, the product was extracted with dichloromethane twice and the organic layer was dried over anhydrous sodium sulfate. After concentration in vacuo, the residue was purified by silica gel chromatography (eluted with 8:1 hexane:AcOEt) to give 8S (1.25 g, 80%) as a white solid.

Provenance & Evidence