Veratrole → 1-Acetoxy-2-methyl-3-(3,4-dimethoxyphenyl)propene

Participants

Reaction Conditions

Reaction Steps

In an argon gas atmosphere, a three necked flask having a capacity of 25 ml was charged with 13.82 g (100 m moles) of 1,2-dimethoxybenzene and 1.87 g (10 m moles) of 3,3-diacetoxy-2-methylpropene having a purity degree of 92.0% by mass. Then, the resultant mixture was mixed with 0.142 g (1 m mole) of boron trifluoride-ether complex at an internal temperature of 18 to 19° C. The mixture was stirred at an internal temperature of 22 to 23° C. for 2 hours. After the reaction was completed, the resultant reaction liquid was subjected to a quantitative analysis using a high performance liquid chromatography. In the result, the target 1-acetoxy-2-methyl-3-(3,4-dimethoxyphenyl)propene was obtained in a yield of 94.4% (amount: 2.36 g).

Provenance & Evidence