4-Chloro-6,7-dimethoxy-quinoline-3-carbonitrile → 4-(6-Chloro-4-iodo-2,3-methylenedioxyan ilino)-3-cyano-6,7-dimethoxyquinoline

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Reaction Steps

Using an analogous procedure to that described in the portion of Example 1 that is concerned with the preparation of starting materials, 4-chloro-3-cyano-6,7-dimethoxyquinoline (1.74 g) was reacted with 6-chloro-4-iodo-2,3-methylenedioxyaniline (2.5 g) to give 4-(6-chloro-4-iodo-2,3-methylenedioxyanilino)-3-cyano-6,7-dimethoxyquinoline as a solid (2.59 g) which gave the following characterising data; NMR Spectrum: (DMSOd6) 4.0 (s, 6H), 6.18 (s, 2H), 7.38 (s, 1H), 7.48 (s, 1H), 7.88 (s, 1H), 8.44 (s, 1H), 9.45 (s, 1H); Mass Spectrum: M+H+ 510.

Provenance & Evidence