1-Acetylpiperazine → HCID 21082718, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 10, 7-(3-chloropropoxy)-3-cyano-6-methoxy-4-[4-(3-methoxyprop-1-ynyl)-2,3-methylenedioxyanilino]quinoline was reacted with 1-acetylpiperazine to give the title compound in 58% yield; NMR Spectrum: (DMSOd6 and CF3CO2D at 100° C.) 2.04 (s, 3H), 2.3–2.37 (m, 2H), 3.27–3.37 (m, 9H), 3.74–3.84 (m, 4H), 3.96 (s, 3H), 4.3–4.36 (m, 4H), 6.04 (s, 2H), 6.89 (d, 1H), 6.96 (d, 1H), 7.51 (s, 1H), 7.96 (s, 1H), 8.66 (s, 1H); Mass Spectrum: M+H+ 572.

Provenance & Evidence