Sodium Hydroxide → HCID 21082674, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl (2E)-3-[4(3-cyano-6,7-dimethoxyquinolin-4-ylamino)-2,3-methylenedioxyphenyl]acrylate (0.75 g), a 1N aqueous sodium hydroxide solution (12 ml) and methanol (45 ml) was stirred and warmed to 40° C. for 12 hours. The reaction mixture was evaporated. Water was added and the mixture was acidified by the addition of 2N aqueous hydrochloric acid solution. The resultant precipitate was isolated and dried. There was thus obtained the title compound as a solid (0.703 g); NMR Spectrum: (DMSOd6) 3.98 (s, 6H), 6.19 (s, 2H), 6.59 (d, 1H), 7.02 (d, 1H), 7.28 (d, 1H), 7.48 (s, 1H), 7.55 (d, 1H), 8.09 (s, 1H), 8.95 (s, 1H); Mass Spectrum: M+H+ 420.

Provenance & Evidence