(2-Methoxyethyl)(methyl)amine → HCID 69461269, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 16, (2E)-3-[4-(3-cyano-6,7-dimethoxyquinolin-4-ylamino)-2,3-methylenedioxyphenyl]acrylic acid was reacted with N-(2-methoxyethyl)-N-methylamine to give the title compound in 47% yield; NMR Spectrum: (DMSOd6) 2.94 (s, 1.5H), 3.08 (s, 1.5H), 3.17 (s, 3H), 3.43–3.65 (m, 4H), 3.95 (s, 3H), 3.96 (s, 3H), 6.1 (s, 2H), 6.84 (d, 1H), 7.16 (d, 1H), 7.25 (d, 1H), 7.33 (s, 1H), 7.43 (d, 1H), 7.76 (s, 1H), 8.48 (s, 1H), 9.62 (s, 1H); Mass Spectrum: M+H+ 491.

Provenance & Evidence