Thioglycolic Acid → HCID 131726235, compound

Participants

Reaction Steps

A 500 mL three-necked round bottom flask was charged with 16.86 g of C4F9SO2N(CH3)CH2CH2OH (MW=357; 47.22 mmol; Example 2, A from WO 01/30873), 4.35 g HSCH2CO2H (MW=92.12, 47.22 mmol; available from Sigma-Aldrich), 2 drops of CF3SO3H catalyst, and 120 mL toluene. The mixture was heated to reflux under nitrogen at 115–120° C. with a mechanical stirrer for 8 hours. Water was removed by azeotropic distillation. Fourier Transform Infrared Spectroscopy (FTIR) analysis indicated the formation of ester. Toluene was stripped using a rotary evaporator (21.35 g solid).

Provenance & Evidence