反应详情

To 457.2 mg. of 1-amino-4-guanidinobutane (IV) suspended in 60 ml. of dry pyridine was added 2-(n-octyl)cyclopropanecarbonyl chloride. This suspension was stirred at room temperature for 40 hours. At the end of 40 hours the solid material was filtered and the filtrate concentrated to a viscous oil, which was chromatographed on silica gel using 30% methanol in CHCl3, resulting in 497.7 mg. of desired material, characterised by EIMS with M+ at m/e 310 for C17H34 -N4O.

1. filtrationAt the end of 40 hours the solid material was filtered
2. concentrationthe filtrate concentrated to a viscous oil, which
3. customwas chromatographed on silica gel using 30% methanol in CHCl3
4. customresulting in 497.7 mg