1-(3-Fluoro-4-(5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yloxy)phenyl)-3-(2-(4-fluorophenyl)acetyl)thiourea → 3-Fluoro-4-(5-methyl-6-(2-(4-methylpiperazin-1-yl)ethoxy)pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)benzenamine

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Reaction Steps

4-(2-Fluoro-4-nitrophenoxy)-5-methyl-6-(2-(4-methylpiperazin-1-yl)ethoxy)pyrrolo[2,1-f][1,2,4]triazine (20 mg, 0.05 mmol) was converted to the title compound (16 mg, 87%) in a manner similar to the preparation of Compound B of Example 28. 1H NMR (CDCl3) δ 7.86–7.83 (m, 1H), 7.50–7.38 (m, 2H), 7.09–7.00 (m, 1H), 6.56–6.45 (m, 1H), 4.14 (t, 2H, J=5.5 Hz), 2.99–2.38 (m, 18H); MS(ESI+) m/z 401.4 (M+H)+.

Provenance & Evidence