2,4-Diaminopyrimidine-5-carbaldehyde → 6-(2-Bromo-6-chloro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

HRID 3475Notes

Reaction equation

HRID 3475 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][C:10]#[N:11].[NH2:12][C:13]1[N:18]=[C:17]([NH2:19])[C:16]([CH:20]=O)=[CH:15][N:14]=1>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:10]([NH2:11])=[N:19][C:17]2[N:18]=[C:13]([NH2:12])[N:14]=[CH:15][C:16]=2[CH:20]=1

Participants

3

Reactant 2

HCID 3091762,4-Diaminopyrimidine-5-carbaldehydeHCID 218500512-(2-broMo-6-chlorophenyl)acetonitrile

Product 1

HCID 218500406-(2-Bromo-6-chloro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Procedure

Prepared as described in Example 1, starting from 1.0 g of 2-bromo-6-chlorophenylacetonitrile and 0.57 g of 2,4-diamino-5-pyrimidine-carboxaldehyde, mp 264°-280° C.; MS(CI).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2dc98d8590054382bf5219d4a3442d75
Source dataset
uspto-grants-1998_03
Patent number
US05733913

Reaction notes

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