反应详情

To 350 mg. of 1-amino-5-guanidinopentane suspended in 70 ml. of dry pyridine was added 700 mg. of 2-(n-octyl)cyclopropanecarbonyl chloride. This mixture was stirred at room temperature for 2 days, after which the solid was filtered and the filtrate concentrated to a brown oil (1.19 g.). The entire bulk of this oil was chromatographed on silica gel eluting with MeOH:CHCl3 (2:3) and collecting 10 ml. fractions. Fractions 20-40 gave 28.8 mg. of desired products. Mass spectrometry (EI): M+ m/e 324 for C18H36N4O.

1. filtrationafter which the solid was filtered
2. concentrationthe filtrate concentrated to a brown oil (1.19 g.)
3. customThe entire bulk of this oil was chromatographed on silica gel eluting with MeOH:CHCl3 (2:3)
4. customcollecting 10 ml
5. customFractions 20-40 gave 28.8 mg