2-Oxo-1-phenyl-1,2-dihydropyridine-3-carboxylic acid → n-(3-Fluoro-4-(2-(pyridin-3-yl)-1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

Participants

Reaction Steps

Prepared in a similar manner as Example 239 using 3-fluoro-4-(2-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzenamine (Compound E of Example 237) and 2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxylic acid. 1H NMR (DMSO-d6) δ 12.87 (s, 1H), 12.18 (s, 1H), 9.39 (s, 1H), 8.70–8.85 (m, 2H), 8.60 (d, 1H, J=7.1 Hz), 8.00–8.25 (m, 3H), 7.94 (s, 1H), 7.30–7.75 (m, 8H), 6.77 (t, 1H, J=6.6 Hz), 6.45 (d, 1H, J=4.6 Hz), 4.21 (s, 2H), 3.68 (s, 2H), 2.43 (s, 6H); LC/MS(ESI+) m/z 518 (M+H)+.

Provenance & Evidence