HRID34756

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66054

Butanoyl chloride, 3-methyl-

C5H9ClO

结构：CCCCCCCCCCCCCC(=O)N(CCCN)CCCCCNc1nc(C)cc(C)n1

HCID14346020

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCC(=O)N(CCCCCNc1nc(C)cc(C)n1)CCCNC(=O)CC(C)C

HCID14346021

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

The primary amine XV was treated with 3-methylbutanoyl chloride in pyridine in the manner described above (C). The crude product was chromatographed on a 24 g silica gel column (BioSil A) of dimensions 1 cm (id)×30 cm, developed with 30% acetone/CHCl3. Five ml fractions were collected. The pure product was found in tubes 14-22, 128 mg.

WORKUP

后处理

customThe crude product was chromatographed on a 24 g silica gel column (BioSil A) of dimensions 1 cm (id)×30 cm
customFive ml fractions were collected

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fe2d28c06bf84c46b92c4d5abeabde8a
来源数据集: uspto-grants-1988_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04762949
来源说明: uspto-grants-1988_08

反应 SMILES

[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]1[N:32]=[C:31]([CH3:33])[CH:30]=[C:29]([CH3:34])[N:28]=1)[C:6](=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].[CH3:35][CH:36]([CH3:41])[CH2:37][C:38](Cl)=[O:39]>N1C=CC=CC=1>[CH3:35][CH:36]([CH3:41])[CH2:37][C:38]([NH:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]1[N:28]=[C:29]([CH3:34])[CH:30]=[C:31]([CH3:33])[N:32]=1)[C:6](=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:39]