tert-Butyl isocyanate → 1-[2-Amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

HRID 3476Notes

Reaction equation

HRID 3476 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:19]([NH2:20])=[N:18][C:12]2[N:13]=[C:14]([NH2:17])[N:15]=[CH:16][C:11]=2[CH:10]=1.[C:21]([N:25]=[C:26]=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[NH2:17][C:14]1[N:15]=[CH:16][C:11]2[CH:10]=[C:9]([C:3]3[C:4]([Cl:8])=[CH:5][CH:6]=[CH:7][C:2]=3[Br:1])[C:19]([NH:20][C:26]([NH:25][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:27])=[N:18][C:12]=2[N:13]=1

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 218500406-(2-Bromo-6-chloro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Product 1

HCID 53291141-[2-Amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea

Procedure

The title compound was prepared using 0.30 g of 6-(2-bromo-6-chloro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 104 and 0.105 mL of tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with 1:1CHCl3 :EtOAc; mp 314° C. (dec); MS(CI).

Workup

  1. customThe product was purified by MPLC
  2. washeluting with 1:1CHCl3

Sources & evidence

ORD record
ord-6e93aa3e0e454f9b818344212ecfd465
Source dataset
uspto-grants-1998_03
Patent number
US05733913

Reaction notes

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