Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3,4,5-tetrahydro-1H-1-benzazepine → 2-Methyl-4-(2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3,4,5-tetrahydro-1H-1-benzazepine | HCID 576503 | — |
| 반응물 | 4-Cyano-3-methylbenzoic acid | HCID 10241099 | — |
| 생성물 | 2-Methyl-4-(2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)benzonitrile | HCID 15896085 | — |
반응 단계
The carboxylic acid from Example C (0.96 g, 5.95 mmol) was reacted with 2,3,4,5-tetrahydro-1H-1-benzazepine (0.80 g, 5.44 mmol) according to the procedure in Example 1A. The product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 30:70); yield 1.10 g (70%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07176195B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-025312a47f9a4c6f9aebb7da116c4574 |
| 출처 메모 | uspto-grants-2007_02 |