反应详情

The amine hydrochloride from. Example 12B (0.132 g, 0.35 mmol) was reacted with 2,6-difluorophenylisocyanate (0.055 g, 0.35 mmol) according to the procedure in Example 1C. The product was purified by flash chromatography on silica (eluant EtOAc:pet. eth r 70:30) and then by preparative HPLC (gradient water:acetonitrile 80:20–20:80; 0.1% TFA). The HPLC fractions were freeze-dried to give a white solid; yield 0.027 g (17%).

1. customThe product was purified by flash chromatography on silica (eluant EtOAc:pet. eth r 70:30)
2. customThe HPLC fractions were freeze-dried
3. customto give a white solid