HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3,4,5-tetrahydro-1H-1,5-benzodiazepine → 1-(4-Cyano-3-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 577192 | — |
| Reactant | 4-Cyano-3-methylbenzoic acid | HCID 10241099 | — |
| Product | 1-(4-Cyano-3-methylbenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 21083241 | — |
Reaction Steps
The carboxylic acid from Example C (0.65 g, 4.03 mmol) was reacted with 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine from Example 15A (0.50 g, 3.36 mmol) according to the procedure in Example 1A. The product was purified by flash chromatography on silica (eluant EtOAc:pet. ether 50:50); yield 0.36 g (37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07176195B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-6a78b70ee21140fabd6dbbdd5bbe8820 |
| Source note | uspto-grants-2007_02 |