反应详情

A solution of 4-amino-2-chloromethylpyrimidine (11.6 g.) in methanol (20 ml.) was added over 15 minutes to a stirred mixture of sodium methoxide (4.32 g.), N-(2-mercaptoethyl)phthalimide (16.6 g.) and methanol (100 ml.), and the mixture stirred for 1 hour after the addition was complete and then evaporated to dryness. The residue was partitioned between 1N hydrochloric acid and ethyl acetate, and the aqueous phase separated and neutralised by the addition of sodium bicarbonate. The mixture was extracted with ethyl acetate and the extracts dried and evaporated to dryness, and the residue was recrystallised from acetonitrile to give 4-amino-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine, m.p. 131°-133°.

1. additionafter the addition
2. customevaporated to dryness
3. customThe residue was partitioned between 1N hydrochloric acid and ethyl acetate
4. customthe aqueous phase separated
5. additionneutralised by the addition of sodium bicarbonate
6. extractionThe mixture was extracted with ethyl acetate
7. customthe extracts dried
8. customevaporated to dryness
9. customthe residue was recrystallised from acetonitrile